Abstract Search

ea0056gp128 | Female Reproduction | ECE2018

Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines

Mancini Francesca , Milardi Domenico , Carfagna Piero , Grande Giuseppe , Miranda Vincenzo , De Cicco Nardone Alessandra , Ricciardi Domenico , Pontecorvi Alfredo , Marana Riccardo , De Cicco Nardone Fiorenzo

Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 710% of women of reproductive age, up to 50% of women with infertility and up to 60% of women with dysmenorrhea. The aim of this pre-clinical study was evaluate the efficacy of low-dose SKA Progesterone (GUNA) and low-dose SKA IL-10 (GUNA) in the modulation of the inflammatory response in endomet...

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ea0099p316 | Pituitary and Neuroendocrinology | ECE2024

The pathogenic RET val804met variant in acromegaly: a new clinical phenotype?

Chiloiro Sabrina , Domenico Capoluongo Ettore , Costanza Flavia , Minucci Angelo , Giampietro Antonella , Infante Amato , Milardi Domenico , Ricciardi Tenore Claudio , De Bonis Maria , Gaudino Simona , Rindi Guido , Olivi Alessandro , De Marinis Laura , Pontecorvi Alfredo , Doglietto Francesco , Bianchi Antonio

Genetic discoveries improved the understanding of the etiology and pathogenesis of several diseases, including acromegaly. Germline mutations involving AIP, MEN1, CDKN1B, GPR101, PRKAR1A, and GNAS genes have been described in GH-secreting PitNETs, but realistically many genetic alterations have not been identified yet. Nowadays, RET mutations have not been reported in acromegaly, if not exclusively in the context of a multiple endocrine neoplasia (MEN). A 48-year-old patient w...

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Endocrine Abstracts

Low-dose SKA Progesterone and Interleukin-10 modulate the inflammatory pathway in endometriotic cell lines

The pathogenic RET val804met variant in acromegaly: a new clinical phenotype?

BiosciAbstracts